Mirtazapine has been a lifesaver remedy for my insomnia. Mirtazapine, unlike nearly all sleeping pills does not terminate SWS delta deep wave restorative sleep or REM sleep.
Some studies show remeron (mirtazapine) actually increases slow wave sleep,
Benzodiazepines, ambien destroy healthy sleep, and basically just knock you out unconscious without allowing the brain to rejuvenate.
Remeron can decrease cortisol by causing sedation. Reduction in norepinephrine signaling by blocking histamine causes a decrease in CRH production, which then results in a reduction in ACTH then cortisol.
Realize that this occurs primarily at night, when the histamine blocking effect of Remeron is the strongest in causing a person to sleep.
In the long run, through its effects on the nervous system and its reduction in norepinephrine signaling at night (in at least the low to mid-range doses), Remeron reduces the severity of depression (after all, it is an antidepressant). This results in a restoration of cortisol signaling in response to stress (i.e. an increase in cortisol signaling, or in other words, a restoration of HPA Axis regulation, which was dysregulated in depression). Then cortisol levels go up.
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