Estrogen is the Causative Factor in BPH, not Testosterone and Nettle plus DHT will reverse this

 estrogen is a causative factor in BPH  

The lignan 3,4-divanillyltetrahydrofuran, also present in nettle root was able to completely inhibit DHT from binding to SHBG, yet another indication that it can result in increased free (active) DHT available to tissues such as that in the scalp.Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).

The root of nettle is widely used to treat benign prostatic hypertrophy (BPH), allergies, arthritis, and inflammation. It is usually combined with herbs such as saw palmetto and pygeum for the treatment of BPH. Several compounds have been isolated from nettle including flavonoid glycosides that appear to contribute to its biological effect

 Nettle extract has reno- ⁽²⁰⁾ and hepatoprotective ⁽²¹⁾ properties. It also demonstrated anti-proliferative effects in human prostate cancer cells ⁽⁶⁾ and protected against cisplatin-induced toxicity ⁽¹⁵⁾. Another study found it effective against colitis in mice ⁽¹⁶⁾.
Data from a few clinical trials suggest benefits of nettle in the treatment of osteoarthritis of hip, knee ⁽¹⁰⁾and hand ⁽¹⁴⁾

Constituents

• Acids: Carbonic acid, formic acid, silicic acid, citric acid, fumaric acid, glyceric acid, malic acid, oxalic acid, phosphoric acid, quinic acid, succinic acid, and threonic acid
• Amines: Acetylcholine, betaine, choline, lecithin, histamine, and serotonin
• Flavonoids: Flavonol glycosides (isorhamnetin, kaempferol, quercetin)
• Other constituents: Choline acetyltransferase, scopoletin, B-sitosterol, and tannins
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Mechanism of Action

In vitro studies show that nettle extract inhibits several inflammatory events that are responsible for the symptoms of seasonal allergies ⁽²⁾. They include the antagonist and negative agonist activity against the histamine-1 (H(1)) receptor and inhibition of prostaglandin formation via inhibition of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and hematopoietic prostaglandin D(2) synthase (HPGDS), key enzymes in pro-inflammatory pathways ⁽²⁾.
A methanolic extract of nettle reduced experimentally induced prostatic hyperplasia in mice ⁽¹⁷⁾.

• Cytochrome P450 substrates: Nettle inhibits cytochrome P450 enzymes and may affect the intracellular concentration of drugs metabolized by these enzymes ⁽⁹⁾.

DHT actually blocks the aromatase enzyme which converts testosterone into estrogens. Thus, in addition to being stronger than testosterone, DHT is a potent aromatase inhibitor.

According to Jonathan Wright, M.D. (Maximize Your Vitality And Potency) the balance of DHT and 4-androstenedione should be 1:1. If DHT is higher and androstenedione lower, it creates a pro-carcinogenic state. However, if DHT and androstenedione levels are both high and at a 1:1 ratio, the pro-carcinogenic properties of high DHT are neutralized by the anti-carcinogenic properties of androstenedione.

Therapeutic DHT can improve the androgen-to-estrogen ratio--without the risk of converting to unwanted estrogens. According to Harrod Buhner: Estradiol--but not DHT--has been found to act with SHBG to cause an eightfold increase in intracellular cyclic adenosine monophosphate (cAMP) in human BPH tissue, which causes increases growth of the prostate. In other words, in cases of enlarged prostate, estrogen is the likely culprit. 

 In one clinical trial, subjects applied a topical gel containing 70 milligrams of DHT but follow-up Prostatic-Specific Antigen (PSA) test numbers, a common blood test for prostate disease, did not increase. Furthermore, test subjects actually developed stronger urine streams, a clinical sign of prostate shrinkage.

In addition to its role in prostate health, DHT is an incredible mood booster and nervine. The brain relies on sex hormones, such as DHEA, testosterone, DHT and estrogen, for optimal functioning, but of all these steroid compounds, DHT reigns supreme. Buhner claims that DHT is more important for brain health than even testosterone, since while testosterone’s neural impact subsides after a few hours, DHT’s neural effect can last up to twenty-four hours.

Dietary fat is critical for sex hormone production and low-fat diets (i.e., fat calories below 25-30%) will cripple your efforts. I get at least 30% of my calories from fat but notice I feel better--and get better workouts--at 40%

avoid saw palmetto, which can block the conversion of testosterone into DHT. Given that DHT is more potent than testosterone, this is the last thing you want. Saw palmetto can also reduce androgen receptor uptake of testosterone and DHT, which just makes things worse. Instead, take nettle root, which shows numerous benefits, including unbinding testosterone and DHT from the glycoprotein sex-hormone binding globulin (SHBG). In other words,

supplementing nettle root can increase free testosterone and DHT levels, making both readily available for use. Secondly, nettle root helps block the conversion of testosterone into estrogen and third, nettle root is great for prostate issues and has been shows to decrease nighttime urination frequency, improve urination power, and help shrink enlarged prostate tissue.

Korean ginseng (look for caps and powder from a six year old root), and Siberian ginseng. One way to raise androstenedione is to supplement DHEA, which can convert into androstenedione, but I prefer (and use myself) magnesium oil, which can naturally increase DHEA levels. The extra DHEA can then spill over into increased androstenedione, which is only one metabolic step away. Magnesium oil is a powerful supplement which can optimize the entire hormone cascade from pregnenelone all the way down to DHT. Siberian Ginseng is also great to ensure the adrenal pathway goes the route of DHEA instead of cortisol. 

If you are prone to baldness, tocotrienols are a must. Tocotreienols are a special form of Vitamin E that help with hair growth and slowing down hair loss. Men that are prone to baldness will accelerate hair loss with ramped up DHT levels.

If your test results indicate excess estrogens, consider supplementing with diindolylmethane (DIM), a phytonutrient which helps convert unwanted estrogens into desirable estrogens. Also Calcium D-glucarate, a calcium salt which can actually clear excess estrogens from the body. 

s Stinging Nettle Root, a known liver protector.  It has in various studies been shown to protect the liver of lab animals from various toxins and poisons, such as aflatoxin and carbon tetracholoride.  Since the bulbine already decreases estradiol,

Bulbine natalensis is a hype in the sports supplement world. It's easy to see why – the effects of extracts of Bulbine natalensis recorded in animal studies are pretty impressive. animal study,

ProLensis is the brand - their high quality bulbine "has been shown in studies to increase testosterone by a whopping 347% and crush estrogen by 35%." Based on  results from 2009 researchers at the University of Ford Hare in South Africa published the results of a study in which they had given male rats water-based extracts of Bulbine natalensis for a week. The researchers pumped the extract directly into the stomach of the lab animals.   The Bulbine natalensis extract  did have an effect at doses of 25 and 50 mg/kg bodyweight.  According to another study by the same researchers, published in 2010, the extract activates enzymes in the testes. [Pharm Biol. 2010 May;48(5):568-76.]

• Stinging nettle (Urtica dioica):  Another natural antihistamine, stinging nettle has a long history of use for seasonal allergies, without the drowsiness and dry mouth associated with many pharmacological antihistamines. Nettle inhibits your body’s ability to produce histamines. The recommended dose is about 300 mg freeze-dried nettle extract daily.