Let's summarize in Bullets Here.
- DHT regulates alpha and beta adrenergic receptors.
- DHT may increase alpha-1-receptor density.
- DHT may decrease glutamate activity and increases mGLU7 expression (which increases GABA release)
- DHT increases serotonin 5-HT1A receptor density by influencing A1-Adr.Receptors.
- DHT promotes serotonin 5-HT1A/1B activity and may reduce aggression in the presence of serotonin. Although this may easily be over ridden by the pro-adrenergic effects of DHT.
- DHT increases beta-endorphin release by ^ 5-HT1A receptor indirect activation.
- DHT facilitates the release of Epinephrine (adrenaline).
- DHT increases cyclic AMP.
- DHT blocks estrogen-induced prolactin release.
- DHT reduces serotonin and serotonin receptors by inhibiting estrogen influence in the Brain. (but mainly acting to oppose 5-HT2A,2C and 5-HT4 receptors)
- DHT increases Mitogen-Activated-Protein Kinase (MAPK) which leads to a variety of molecular changes and genomic changes as well as neural-changes; decreased serotonin activity in the brain and periphery.
- DHT increases GABA and GABA-A (neurosteroid-specific) receptor expression.
- DHT increases NMDA-receptors in the Hippocampus.
- DHT increases Ca3 (Calcium) evoked Acetylcholine Function(AcH release).
- DHT increases nervous system strength and regulates blood pressure.
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