In healthy individuals there does not appear to be any adverse effects of a high protein diet. In a study on bodybuilders consuming a high protein (2.8 g·kg-1) diet no negative changes were seen in any kidney function tests
casein has been shown to provide the greatest benefit for increases in protein synthesis for a prolonged duration. However, whey protein has a greater initial benefit for protein synthesis. These differences are related to their rates of absorption. It is likely a combination of the two could be beneficial, or smaller but more frequent ingestion of whey protein could prove to be of more value
If the kidneys are unable to buffer the high endogenous acid levels, other physiological systems will need to compensate, such as bone. Bone acts as a reservoir of alkali, and as a result calcium is liberated from bone to buffer high acidic levels and restore acid-base balance
It all comes down to the Amino Acid Utilization (AAU™) that EAA MAP which is dramatically greater than dietary protein sources. AAU reflects the amount of amino acids from a protein source that your body is actually absorbing and utilizing.
- At the low end of the spectrum are branched chain amino acids – only 1% of their content is utilized by the body, with 99% resulting in waste that your body must then process and eliminate.
- Next are whey and soy proteins – only 18% or less of their content is utilized by the body with 83% leaving as waste.
- Food like meat, fish and poultry fare just a bit better, with 32% being absorbed and 68% being wasted.
- Eggs are the winners in the food category with 48% being utilized and 52% converted to waste.
It was found that you see significant muscle-preserving effects from essential amino acid supplements when ingested, especially during training in a fasted or ketotic state. This includes decreased indicators of muscle damage and maintenance of a healthy inflammatory response. [1]
This means that if you took some essential amino acids, and consumed nothing else, you wouldn’t “cannibalize” as much lean muscle during a fasted workout session.
It would be the same for working out during or after a long intermittent fast, a bout of ketosis
Then there is the study showing that consuming an essential amino acid mix after intense resistance training actually increased muscle protein growth
Plainly, simply, and honestly, it shortens recovery time both during and post-workout by a significant amount. I have more endurance, as my body doesn’t feel like it’s breaking down, and my recovery time is near extinct.
I’m able to continue pushing on long runs and hills without feeing as if I’ve already put in hours of running before. I can go on a hard 10 mile tempo run and feel absolutely fine ten minutes. I can run for five hours and feel like I just started.
Fatigue is no longer an issue for me, and that’s one hell of a claim as an endurance runner.
Outside of running, I’ve noticed a bit more energy, but nothing nearing the drastic change I’ve seen during my workouts. “feels that (his) body is firing on all cylinders.” He also says that “it works better than anything else (I) have used–protein shakes, recovery powder, etc.
Go out and do some damage and wake up the next day feeling nearly ready do it all over again.”
MAP increases endurance strength because the formula increases the energy hormone, ATP (adenosine-triphosphate) released through the burning of hydrogen.
Mother’s breast milk has the highest NNU of any “food” available at around 50%, with all other foods falling less efficiently after tha
Essential Amino Acids to cause muscle growth and regeneration because they are a potent rapamycin complex 1 (mTORC1) activator (activates cell growth), causing muscle satellite cell proliferation (for healing after injury). This gives them similar muscle building potential as to a large steak, but WITHOUT the large number of calories, preparation time or digestive strain.[3]
as you get older, your muscles produce less, or have a delayed ability to proliferate satellite cells in response to exercise. This is bad, especially when considering that satellite cells are essential for skeletal-muscle regeneration. However, it was found that those who consumed these Essential Amino Acids after resistance exercise had a far greater satellite cell proliferation capacity than those who didn’t supplement. [4]
The Essential Amino Acids in PerfectAmino INCLUDE the 3 BCAAs but ALSO have the other 5, and in the exact ratio that is perfect for you.
This means that EAAs, unlike BCAAs, have a natural anabolic effect AND don’t spike your blood sugar
Take 5-10 grams of PerfectAmino every day. It will be in your system within 23 minutes or less. On days you are doing resistance training, or if you’re not feeling well, take another 5-10. And if you’re training extremely hard, or if you’re recovering from surgery, take yet another 5-10. Just don’t exceed 30 in a day — PerfectAmino is very potent.
- TRYPTOPHAN encourages the release of vital neurotransmitters and hormones for mood and sleep, such as serotonin and melatonin.*
- LYSINE, if deficient, may result in a niacin deficiency (Vitamin B), as well as slow connective tissue repair.*
- METHIONINE supplies sulfur and the other compounds you need for optimum metabolism and growth.*
- VALINE is needed for your muscle fibers to fire, for tissue repair, and for the maintenance of proper nitrogen balance in the body.*
- LEUCINE stimulates muscle protein synthesis and may be the dominant fuel involved in anabolic (tissue building) reactions.*
- ISOLEUCINE is essential for blood sugar regulation, muscle development and repair, and energy regulation.*
- THREONINE is crucial for antibody production, immune system activity, and can be converted into glycine and serine.*
- PHENYLALANINE stimulates the release of neurotransmitters and hormones, which are necessary substances for optimum activity of your central and peripheral nervous systems.*
- THE ROYAL NATIONAL ACADEMY OF MEDICINE OF SPAIN – VOLUME CXV - SECOND ISSUE – MADRID, 1998. 1 A Comparative, Double-blind, Triple Crossover Net Nitrogen
- The results of comparative, double-blind, triple and quintuple crossover Net Nitrogen Utilization® (NNU®) clinical studies1-10 have shown that the subjects, while taking MAP™, as a dietary proteins substitute, achieved a body's 99% NNU®.
- This means that 99% of MAP™'s constituent amino acids followed the anabolic pathway, thus acting as precursor of body's protein synthesis (BPS), namely as “building blocks”. By comparison, dietary proteins only provide an average between 16 to 32% NNU
- Since 1992, the results of forty-six scientific clinical studies1-46, performed in human subjects, have shown that MAP Master Amino Acid Pattern® can substitute dietary proteins in a safer and nutritionally more effective way.
- This means that 1 g (1 tablet) of MAP Master Amino Acid Pattern® provides a Body Protein Synthesis (BPS) equivalent to that provided by at least 2.5 g of any high biological value dietary protein, requiring, however, a digestion time 6 to 12 times shorter than the one required by dietary proteins.
- A protein’s NNU® (%) is the unit of measurement for Body Protein Synthesis (BPS) and is synonymous with a protein's nutritional value. NNU® (%) is the percentage of digested protein’s constituent amino acids following the anabolic pathway to act as precursors for BPS. A protein’s NNU® (%) can be calculated through a methodology known as “Body Nitrogen Balance”.
- dietary proteins release an average of 68% nitrogen catabolites. Meanwhile, protein supplements release 84% nitrogen catabolite MAP™ may minimize both the intensity and duration of digestive functions compared to any dietary protein or protein supplement.
- Regarding protein, only 18% or less of whey and soy protein is utilized by the body with 83% leaving as waste. Protein from such sources as meat, fish and poultry are absorbed at 32%, with 68% wasted. Eggs are utilized at 48%, with 52% converted to waste
- MAP™ is absorbed in the small intestine within 23 minutes from its ingestion. By comparison, dietary proteins and protein supplements need from 3 to 6 hours to be digested.
- For professional athletes: 10 tablets of MAP™, thirty minutes before training, in conjunction with the daily requirement of vitamins, minerals and trace elements. And an additional 10 tablets of MAP™ to be taken two hours after working out. Notice: Never take more than ten tablets of MAP™ within a two-hour period
- Yes. MAP™ should always be taken in conjunction with the daily requirement of vitamins, minerals and trace elements.No. Protein supplements should not be taken in conjunction with MAP™, in order to prevent:
- a decrease in Body Protein Synthesis;
- an increase in metabolic toxic waste, namely nitrogen catabolites (BUN); and
- an overloading of digestive functions
- Dr. Grandi, he recommended taking twenty (20) per day and a minimum of thirty per day during hard training and/or competition. Holy cow!
- Amino Acid Formula of the Master Amino Acid Pattern (g)
L-Isoleucine 1.48
L-Leucine 1.96
L-Lysine 1.11
L-Valine 1.657
L-Methionine 1.429
L-Phenylalanine . 699
L-Threonine 1.289
L-Tryptophane 0.368
Total 10.000 - Due to such characteristics, the utilization of MAP could be highly beneficial in the dietary treatment of patients
with:
a) Protein-Energy Malnutrition (PEM);
b) Anorexia;
c) Bulimia;
d) Renal insufficiency;
e) Hepatic insufficiency;
f) Anemia due to an insufficient erythropoiesis;
g) Lack of appetite;
h) Vomit;
i) Uncontrollable diarrhea;
j) Excessive catabolism;
k) Obesity. - Muscle synthesis in your body is most efficient when there are free essential amino acids in your blood plasma.* Your body is able to adapt to differences in protein intake, but it needs free amino acids for improved muscle synthesis and effective control of your metabolism. Taking essential amino acid supplements have been shown to effectively raise plasma amino acid levels in both young and elderly people, which sets the stage for ideal muscle synthesis.*
- two studies supported by NASA and conducted by scientists from The University of Texas Medical Branch, researchers established that essential amino acid supplementation robustly stimulated net muscle protein synthesis even when subjects were put on bedrest. These studies were done to find what would correct the effects of inactivity due to spaceflight, illness, injury, or aging.
- Here are key findings from these two studies:
- Taking essential amino acids at the ratios found in Oh!mino®produces a rapid, several-fold increase in plasma amino acid levels.*
- Essential amino acid supplementation stimulates overall muscle synthesis better on its own than when mixed in a solution or meal containing other non-essential amino acids (protein powder).*
- Taking an essential amino acid supplement without the presence of carbohydrates or proteins produces a more potent muscle synthesis response.*
- Essential amino acids without added carbohydrates or proteins won’t increase insulin and therefore are great for anyone worried about insulin resistance or glycemic effects.*
- Essential amino acid supplementation can preserve muscle mass loss due to bedrest.*
- In one of these studies, there was an actual increase in type 1 muscle fibers in the bedrest group who took the essential amino acid supplement. -----------------------------
------------------------------ ------------------------------ ------------------------------------------------------ ------------------------------ ---------------- EAA + Leucine handily defeated EAA + BCAA
it’s been known since 1966 that they may impede leucine’s absorption in the gut![25] Further, the three branched aminos even compete for the same transporter at various sites,[26] so why not try to get a bit more of the anabolic one (leucine) if you’re trying to build muscle?!studies investigating, the influence of leucine co-ingestion with EAA (Glynn et al., 2010), or intact protein (Koopman et al., 2005, 2006, 2008; Tipton et al., 2009; Wall et al., 2013) on the stimulation of MPS in young men report equivocal results. Whereas, the addition of leucine to whey protein failed to enhance the post-exercise response of MPS (Koopman et al., 2005, 2008; Tipton et al., 2009), adding leucine to a casein protein source was shown to increase the resting postprandial stimulation of MPS muscle protein synthesisfull complement of EAA could be necessary to stimulate a maximal response of myofibrillar-MPS following resistance exercise.oral supplementation with BCAA following resistance exercise stimulates mTORC1 signaling more potently than ingestion of leucine alone, but not as effectively as EAA.
My kidney lab values have been consistently better while taking this product. (in place of a higher meat or grain protein meal) Just once a day. Creatinine has gone from stage 4 numbers ( 8 ) down to normal, over the three years - -----------
------------------------------ ------------------------------ ------------------------------ ------------------------------ --- - Consuming more protein will thus have no effect after a certain level (approximately 0.8-1.0g per pound of body weight).In fact, overconsuming protein can even stall muscle gains in natural athletes. First, it mobilizes glutamine from the muscle (so breaks down muscle to release glutamine) to decrease systemic acidity. Overconsuming protein without an adequate intake of vegetables makes the body acidic and it must mobilize glutamine or phosphorus/calcium to fight this acidosis.Second, overconsuming protein also increases the synthesis of protein into glucose to utilize as a form of energy (neoglucogenesis). If the body becomes skilled at this, more protein is used as a form of energy and less is used to build muscle.
- Training stimulates mTor in itself. The two types of contractions that have the greatest effect are accentuated eccentrics (lowering a weight slowly while maximally contracting the muscle) and loaded stretching (reaching the point where the target muscle is stretched during an exercise).However, certain amino acids also have an effect on mTor, the most powerful one coming from leucine. When the body detects an increase in leucine, mTor is activated and this places the body in “construction” mode.
- L-Leucine : Activates mTor and initiates protein synthesis, placing the body into construction mode.L-Citrulline : In my opinion, the second most important ingredient in the product. Citrulline increases recovery and cardiovascular performance via the dilation of blood vessels. In bodybuilding, this increases blood flow to the muscles. During training, it gives a better pump, and during the recovery period, it facilitates the transport of nutrients towards the muscles. Citrulline also has positive effects on cardiovascular health like the decrease of blood pressure, among others.L-Taurine : Taurine has a bad reputation because it has been used as an ingredient in energy drinks and has thus been associated with stimulants, which is not the case. In fact, taurine actually calms the nervous system. Companies that manufacture energy drinks use it as an ingredient for two reasons: 1) to reduce the adverse health effects (taurine decreases blood pressure) and 2) it has a calming effect after the initial stimulus of the drink, thereby motivating consumers to buy a second drink. Taurine helps with nervous system recovery, which is very important for strength gains. Because of its calming effect, it can also decrease cortisol. If cortisol levels remain low, it is easier to build muscle. Note that taurine also has positive effects on cardiovascular health.L-Alanine : This amino acid is quite anti-catabolic : it protects muscle tissue. It also supports the conversion of glucose into energy and has a detoxifying effect on the liver. Although not as “sexy” as citrulline or leucine, its effect on recovery is significant.L-Carnitine : Carnitine plays a significant role in the production of energy by improving the efficiency of the utilization of lipids for energy. As for recovery, it increases the sensitivity of androgenic receptors which accelerates muscle gain and reduces soreness.Isoleucine et Valine : These two amino acids along with leucine are what we call BCAAs (Branched Chain Amino Acids). They have a significant impact on protein synthesis: leucine in the most anabolic, followed by isoleucine and then valine. Isoleucine and valine are also useful for recovery because they increase muscle glucose transport and storage.
- most direct ways of increasing protein synthesis is by activating mTor. We can consider mTor to be the “ON” button of protein synthesis.Training stimulates mTor . Leucine stimulates mTor this individual effect is lost if the elevation of each specific amino acid is masked by an overall elevation of amino acids (by consumption of a large quantity of complete proteins). First, because certain amino acids compete for the transporters that are necessary for their utilization (for example, isoleucine and valine both need tryptophane to get to the brain), and second, because the body does not detect the elevation of certain amino acids if the total level of amino acids is too high (it’s kind of like pouring a glass of water into a pool)
- Gironda was the first to popularize a diet high in fat/low in carbs to reach competition physique. He was also the first to recommend the use of digestive enzymes, because he understood that the secret lies not in the quantity of protein that you consume, but in the quantity that you absorb.He invented the concept of amino acid pulsing: every 1 to 2 hours, his clients consumed 1-2 capsules of amino acids and 1-2 capsules of dehydrated liver. The goal was to prevent all catabolism and to keep the body in construction mode.
- the concept of amino pulsing is to reduce the number of protein meals as well as the total quantity of protein consumed during the day (for example, consuming protein 3 times per day rather that 5 or 6 times like most bodybuilders), and consume specific amino acids between meals.When the total level of protein is lower, the key amino acids will elicit the desired pharmacological effect.
observational and experimental studies found an association between meal timing, weight gain, hyperglycemia and diabetes mellitus with benefits deriving from an early intake of food in the day
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