Saturday, July 20, 2013

eggplant cures skin cancer

(NaturalNews) When it comes to skin cancer, Big Pharma offers only topical chemo creams and surgery. The chemo creams often don't work but often do cause ugly, painful side effects. Removing skin cancer tumors surgically usually results with tumors resurfacing sooner or later. Surgeries often leave ugly scars.

However, there are inexpensive, effective, safe cures for curing skin cancer that are banned by the mainstream medical monopoly, which are not publicized by the mainstream media.

A relatively new remedy, BEC5, is a spin off from an Australian folk remedy for farm animals. It is available to anyone online. It uses the phyotonutrients extracted from eggplants. Clinical trials and anecdotal testimonies confirmed BEC5's efficacy and safety on basal cell and squamous cell cancers.

Melanoma is the least common but most dangerous skin cancer with the highest morbidity rate. It can metastasize into internal organs. The maker and distributors for BEC5 make no claims for curing melanoma so far. But at least one person who made a homemade version that anyone can make claimed it cured his melanoma.

The homemade remedy involves a solution of vinegar and eggplant that extracts the same phyotonutrient glycocides and glycoalkaloids contained in BEC5 directly from the eggplant. The glycoalkaloids penetrate cancer cells selectively and destroy them. Normal cells are left alone.

How to make and use the homemade eggplant remedy

This is an attempt at disclosing what others report cured their skin cancers. It's purely educational and not meant as medical advice. Some of the anecdotal reports had their skin cancer diagnosed by MDs, with subsequent cures confirmed by MDs (1).

Some have used white vinegar, while others recommend raw organic apple cider vinegar. Get a medium sized eggplant and grind it up. Put that into a glass jar and fill it up with the vinegar. Place the jar into the refrigerator. After around three days with the white vinegar, the liquid should turn to a brownish gold color. That indicates it's ready to use.

Apple cider vinegar is already a similar color, but three days seasoning in a refrigerator should be enough.

Apply it directly to tumors often with a cotton ball, or secure the soaked cotton onto the tumor with tape. Treatment may take a couple of weeks or more. Both commercial BEC5 cream and the homemade version also work on warts and other unhealthy skin conditions.

One user mentioned that according to his doctor (naturopath?), if the homemade procedure is painful, then it is melanoma that's under attack. Many of these homemade remedy users were in Australia, where Dr. Bill Cham, MD, PhD, found out about the Devil's Apple plant used by veterinarians and farmers to cure skin cancers on farm animals.

Dr. Cham claims a high, safe cure rate with non-melanoma skin cancers from his own clinical testing. Detractors claim there are no published reports in medical journals. That could be due to the fact that Dr. Cham had to go it alone testing his cream on skin cancer patients in the UK hospital system. Dr. Cham demonstrates and explains his BEC5 cream in a video (2).

Mainstream medicine always attacks natural non-pharmaceutical cures and their sponsors. However, a well known physician, Dr. Jonathan Wright MD, founder of the holistic Tahoma Clinic in the Seattle Washington area, backs up Dr. Cham. Dr. Wright sells BEC5 creams and explains how it works and how it was tested within the UK system (3 - 4).

Dr. Cham determined that the same curative glycoalkaloids were available in eggplant. From there he went on and pioneered the development of BEC5 in London.

Sources for this article include:

Original source for this article http://www.naturalnews.com/027506_eggplant_skin_cancer.html

Learn more: http://www.naturalnews.com/035471_skin_cancer_cure_eggplant.html#ixzz2ZcFAH4xh

Saturday, July 13, 2013

progesterone for domination over estrogen

The three human estrogen hormones have numerous effects on the body which are believed to require progesterone to balance excessive estrogen and prevent the hyper effects of estrogen dominance which can lead to a host of health problems. It is not the absolute deficiency of estrogen or progesterone rather it's believed to be the relative dominance of estrogen and relative deficiency of progesterone that is the main cause of health problems when they are off balance.

 Estrogen dominance is the term used to describe what happens when the ratio of estrogen to progesterone is changed, either by excess estrogen, or insufficient progesterone. The symptoms of estrogen dominance differ from woman to woman, but can range from uncomfortable symptoms such as insomnia, dizziness, irritability, and difficulty concentrating, to extreme changes in mood, bloating, weight gain, muscle pain, joint pain, and urinary incontinence. Other possible symptoms of low progesterone may include frequent urinary tract infections, interstitial cystitis, changes in appetite, hot flashes, cold chills, night sweats, and vaginal dryness and any of these:
 Allergies and Asthma
Missed or irregular periods
Swollen or Fibrocystic Breasts
Fatigue
PMS
Infertility
PCOS
Fibroids
Magnesium deficiency
Thyroid dysfunction

 Progesterone is believed to have the following counterbalancing effects on the estrogen hormones:
 matures the uterine lining preventing excess buildup of tissue
inhibits breast tissue overgrowth, preventing fibrocystic breast disease
has a diuretic effect which mobilizes fluid, decreasing swelling
enhances the action of thyroid hormones, increasing metabolism
stimulates the production of new bone, protecting against osteoporosis
increases the sex drive • protects against breast cancer and uterine cancer
thins the blood, preventing blood clots
supports the function of the adrenal glands
elevates mood
promotes pregnancy

 From age 35 to 50, there is a 75% reduction in production of progesterone in the body. Estrogen, during the same period, only declines about 35%. By menopause, the total amount of progesterone made is extremely low, while estrogen is still present in the body at about half its pre-menopausal level. With the gradual drop in estrogen but severe drop in progesterone, there is insufficient progesterone to counteract the amount of estrogen in our body. Many women in their mid-thirties, most women during peri-menopause (mid-forties), and essentially all women during menopause (age 50 and beyond) are overloaded with estrogen and at the same time suffering from progesterone deficiency because of the severe drop in physiological production of this hormone during this period. The end result is excessive estrogen relative to progesterone, a condition we call estrogen dominance.

According to Dr. John Lee, the world's authority on natural hormone therapy, the key to hormonal balance is the modulation of progesterone to estrogen ratio. For optimum health, the progesterone to estrogen ratio should be between 200 and 300 to 1.

Progesterone functions in many capacities. It is often taken to counter the effects of estrogen, normally used by women who are postmenopausal. It also goes by the prescription. Natural progesterone is available as well and is known to have far fewer side effects. Progesterone has many functions. First, it is both a precursor to other adrenal hormones and is a GH stimulant as well. It likewise promotes lipolysis (breakdown of fat) and protects against endometrial cancer. It is known to eliminate the risk of endometrial cancer when given with estrogen for 10 or more days per cycle. Lastly, progesterone normalizes levels of blood sugar, zinc, and copper. Progesterone stimulates the walls of the uterus to prepare it for implantation of the fertilized ovum. If pregnancy occurs, progesterone inhibits ovulation (by suppressing FSH & LH) and promotes uterine development until the placenta becomes more mature. (Progesterone is so-named because it promotes gestation, i.e., the growth of offspring in the womb).
USP Progesterone

The title "USP Progesterone" or (USP) differentiates natural progesterone from synthetic progesterone. This means the progesterone which is formulated is identical (bio-identical) to that what is secreted from the female ovaries. Although it is done in a laboratory, no chemicals are added to it, they are simply chemically modified in a special conversion process. USP stands for United States Pharmacopoeia and indicates that the Progesterone meets the standards set in the U.S. "Micronized" USP Progesterone, is the natural form of progesterone broken down into very tiny particles. The process of micronization allows for steady, even absorption of the USP Progesterone.
Symptoms of Low Progesterone

Symptoms related to low Progesterone hormone levels:Tender Breasts Weepiness - Tearfulness Cyclical Headaches-Migraines
Mood Swings - PMS Anxiety & Moodiness Low Libido Irritability & Quick to Anger
Water Retention Fibrocystic or Lumpy Breasts Leg Cramps when Walking
Weight Gain - Hip Area Uterine Fibroids Short Term Memory Loss
Breast Enlargement Puffiness and Bloating Heavy Menses
Rapid Unexplained Weight Gain Thyroid problems Sleep Disturbances - Insomnia
Fungal or Candida Infections Vaginitis and Vaginal Infections Sugar Cravings - Hypoglycemia
Weight Gain-mid body-Waist Infertility Elevated Triglycerides
Not ovulating Anxiety Type Depression Early Pregnancy Miscarriage
Rapid Mood Swings Adrenal Problems-Fatigue Cystic Ovaries-Polycystic Ovary
Bleeding Changes Cold Body Temperature Irregular Periods
Painful Menstrual Cramps Gallbladder Problems Early life Hysterectomy
Early Miscarriages Anxious Irritability Red Palms - Red Fingertips
Feeling Crazy Anxious Red flush on face or sides of neck
Depression Cervix Problems Stress related symptoms

Men & Progesterone

Why some men use progesterone:
 Men need it to make testosterone and for the adrenal glands to make cortisone
Men with BPH (swelling of the prostate) and other male related problems report that they experience some relief with progesterone cream
Progesterone has NO feminizing characteristics
Men report that it helps them with complexion and increases energy
It is believed to help balance the estrogens that build in a man's body
because progesterone levels drop, estradiol levels rise, and testosterone changes in form in older men
Adding progesterone back into the body helps restore normal inhibition of 5-alpha-reductase, thus preventing testosterone from changing into dihydrotestosterone (DHT), which stimulates proliferation of prostate cells
If men have low progesterone levels their estradiol levels can increase. This increase can lead to cancer of the prostate, just as it leads to breast and uterine cancer in women
Low Progesterone Risk Factors
Estrogen

Sometimes the body will produce too much estrogen in certain cases such as in cases of obesity and with hormone medication. Fat cells hold and produce estrogen, so essentially the more body fat you have, the more estrogen is being produced in your body, this will, in turn, lower the levels of progesterone that is produced naturally.
 Insulin

When a person's body has a tolerance to insulin production, this can cause the hormones to become imbalanced, lowering the progesterone production in the body. Resistance of insulin all-together is a leading factor as well.
Stress

A high stress lifestyle will also effect the body's ability to create and produce progesterone. Strenuous physical stress as well as mental trauma and anxiety severely alters the body's hormones and their productivity.
Diet

Malnutrition will not only affect your internal vital organs, but your hormone production as well. In order for your body to pump hormones like progesterone through the body, proper nutrition should be followed.
Inactivity

Refraining from regular exercise causes hormones to sometimes go dormant or decrease production. This causes trauma to the hormone producing glands in the body, therefore hindering the ability to release needed progesterone.
Medications

Depending on the medication you're on, it can affect the amount of progesterone your body produces and absorbs. Certain hormone treatments alter the body's ability to absorb naturally produced hormones, such as progesterone, and even estrogen or testosterone.
 Mysteries

Sometimes, doctor's can't figure out the particular cause of low progesterone, in each woman, that is why it's best to exercise proper nutrition paired with an active and healthy lifestyle. Avoid drinking and eating from plastic containers, and especially avoid reheating food in plastic containers. Doctors have found a link in many progesterone related symptoms with the consumption of materials in plastic containers and receptacles.
Common Questions
Why do women need progesterone?

Progesterone is important in balancing and counteracting the effects of estrogen. But progesterone levels may drop to near zero in some women while their estrogen levels drop only 40-60% at menopause, which is just enough to stop the menstrual cycle. Using progesterone therapy can greatly enhance overall hormone balance because it is the precursor to so many other hormones. It can also stimulates bone-building helping to protect against osteoporosis.
Why do men need progesterone?

Men naturally need progesterone to make testosterone and for the adrenal glands to make cortisone. It balances the estrogens that build in a man's body, it helps men with complexion and it increases energy. Men with BPH (swelling of the prostate) and other male related problems will experience a relief with progesterone cream. Adding progesterone back into the body also can help restore normal inhibition of 5-alpha-reductase, thus preventing testosterone from changing into dihydrotestosterone (DHT), which stimulates proliferation of prostate cells.
What is progesterone made from?

The USP progesterone used for hormone replacement comes from plant fats and oils. Wild yams from Mexico, soybeans, and yellow ginger provide a substance called diosgenin. Diosgenin is chemically synthesized into real human progesterone in the laboratory. The other human hormones, including estrogen, testosterone and the cortisones are also synthesized from diosgenin.
 Does increasing progesterone levels help me if I have estrogen dominance?

 When you have inadequate levels of progesterone, it causes your estrogen levels to go up.
Will increased progesterone cause feminine characteristics in men?

No, progesterone has no feminizing characteristics.

most doctors don’t realize progesterone antagonizes and inhibits the enzyme (called 5-alpha reductase) that is needed to make testosterone into dihydrotestosterone. Dihydrotestosterone is the powerful male hormone that talks hair follicles into making coarse hair and too much oil that causes acne.”

lack of progesterone in women with PCOS leads to an imbalance in the ovaries, causes the stimulation of higher male hormones

progesterone signals hypothalamus and pituitary to stop the
ovary from making too much testosterone

oysters are powerhouse of nutrition, Mat Lalonde Harvard Organic Chemist

oysters are powerhouse of nutrition

collagen does help joints

native collagen had no stimulatory effect on chondrocytes, but cells fed the hydrolyzed collagen increased their production of type II collagen 250 percent.

It is very plausible that collagen hydrolysate, when taken as a supplement to our normal diet, may help activate the synthesis of collagen in cartilage. Particularly in situations in which cartilage is under massive stress [e.g., arthritis, obesity, sports injury, etc.], the intake of collagen hydrolysate could be highly significant and reduce degenerative changes.”

Sunday, June 23, 2013

No Substitute for Liver, It will give you more stamina than the energizer bunny

So what makes liver so wonderful? Quite simply, it contains more nutrients, gram for gram, than any other food. In summary, liver provides:
  • An excellent source of high-quality protein
  • Nature’s most concentrated source of vitamin A
  • All the B vitamins in abundance, particularly vitamin B12
  • One of our best sources of folic acid
  • A highly usable form of iron
  • Trace elements such as copper, zinc and chromium; liver is our best source of copper
  • An unidentified anti-fatigue factor
  • CoQ10, a nutrient that is especially important for cardio-vascular function
  • A good source of purines, nitrogen-containing compounds that serve as precursors for DNA and RNA.

ANTI-FATIGUE FACTOR

Liver’s as-yet-unidentified anti-fatigue factor makes it a favorite with athletes and bodybuilders. The factor was described by Benjamin K. Ershoff, PhD, in a July 1951 article published in the Proceedings for the Society for Experimental Biology and Medicine.
Ershoff divided laboratory rats into three groups. The first ate a basic diet, fortified with 11 vitamins. The second ate the same diet, along with an additional supply of vitamin B complex. The third ate the original diet, but instead of vitamin B complex received 10 percent of rations as powdered liver.
A 1975 article published in Prevention magazine described the experiment as follows: "After several weeks, the animals were placed one by one into a drum of cold water from which they could not climb out. They literally were forced to sink or swim. Rats in the first group swam for an average 13.3 minutes before giving up. The second group, which had the added fortifications of B vitamins, swam for an average of 13.4 minutes. Of the last group of rats, the ones receiving liver, three swam for 63, 83 and 87 minutes. The other nine rats in this group were still swimming vigorously at the end of two hours when the test was terminated. Something in the liver had prevented them from becoming exhausted. To this day scientists have not been able to pin a label on this anti-fatigue factor."

Tuesday, June 18, 2013

Get Switched ON! Down your Eggs like Rocky and Speed up your brain by boosting ACH acetyl choline

During the course of the normal aging process, concentrations of ACh tend to decrease, resulting in the sporadic lapses of short-term memory that many elderly individuals tend to experience erupting to Alzheimer's if not checked.

Significant loss of cholinergic neurons is one of  the most significant biological explanation for this devastating Alzheimeir's condition.  Some of Ach functions include: the conduction of pain, the regulation of neuroendocrine function, the regulation of REM sleep cycles, and the process of learning and memory formation.  These neurons send major projections to the hippocampus, a structure particularly important for the normal formation of declarative memories.

Scientists have discovered that choline is necessary to produce phosphatidylcholine (PC).  Phosphatidylcholine is  crucial to synthesize a low density lipoprotein (VLDL) particle, which we need    to export fats from our livers.  Methionine acts as a precursor to choline and can  convert to phosphatidylethanolamine, which finally ends ups as phosphatidylcholine.


Thus, the combined deficiency of choline and methionine will severely impair our livers ability to release fats into the bloodstream.
Animal and plant foodsCholine (mg)
32 gram sunflower lecithin syrup544

15 gram soy lecithin granules450
5 ounces (142 g) raw beef liver473 
Large hardboiled egg113 
1 Whole raw egg,has over an average of 100mg of choline!
 Most experts believe you should eat the whole egg raw, which is also one the highest quality protein sources on the planet. 

Only diseased chickens lay salmonella-contaminated eggs. If you are obtaining high quality, cage-free, organic eggs , the risk virtually disappears. *****

Acetyl-N-Carnitine is a kind of amino acid that is able to increase the production of acetylcholine by donating a small molecule called acetyl (which is made up of two carbons atoms, three hydrogen ones, and an oxygen atom) to another compound, which is known as choline. Once choline receives this acetyl molecule, it becomes acetylcholine (hence the name). Taurine, another amino acid, has been shown to increase the levels of acetylcholine in the hippocampus, which is a part of the brain. 

Dehydroepiandrosterone (DHEA) and 

pregnenolone thrusts the release

 of acetylcholine in the hippocampus.  


This include dimethylaminoethanol (DMAE) which is a drug that slows the breakdown of choline in tissues outside of the brain. As a result, more choline is available to be turned into acetylcholine.

By adding a methyl group (CH3) to DMAE, choline (also called trimethylaminoethanol) is formed. The choline thus formed may then be used to make other valuable biochemicals, such as the major neurotransmitter acetylcholine.

Another drug, pyroglutamate, is also able to increase acetylcholine production by enhancing the production of other chemicals that cause more acetylcholine to be made.
Certain B vitamins are critical for the synthesis of acetylcholine, and a deficiency in them can cause decreased acetylcholine production. These include vitamin B1, B5, and B12.


Ginkgo biloba, stimulates the brain's adsorption of acetylcholine, and the lipid phosphatidylserine,  aids in the production and release of acetylcholine into the brain and reduces cortisol secretion.

GPC Choline (L-alpha-glycerylphosphorylcholine) is one of the best forms of choline to take as it is easily absorbed by the body.

Acetylcholine is important for memory and learning and is a neurotransmitter used throughout the body.  It controls muscle contraction for example.  Acetylcholine may be extremely important for long term memory and   It determines your brain speed.

  In contrast Anticholinergics generally have antisialagogue effects (decreasing saliva production), and most produce some level of sedation.

If you have too little, your brain is going to slow down.  The most extreme case of this is Alzheimer’s.   You can think of acetylcholine as a lubricant for your brain and body.  Acetylcholine along with dopamine are the neurotransmitters that turn your brain on.  They allow it to work hard and fast.  A lack of either one can lead to memory and attention problems.

Modafinil, Armodafinil, and Adrafinil are H3  (histamine receptor 3 antagonists) H3 antagonists also shove up concentrations of  extracellular acetylcholine , brain histamine,  noradrenaline,  & dopamine that are known to modulate cognitive processes. The ability to release brain histamine supports the effect on attention and vigilance, but histamine also modulates other cognitive domains such as short-term and long-term memory.   

Modafinil elevates hypothalamic histamine levels,[6] leading some researchers to consider modafinil a "wakefulness promoting agent" rather than a classic amphetamine-like stimulant.[7] Modafinil seems to inhibit the actions of the dopamine transporter, thus leading to an increase in extracellular and thus synaptic concentrations of dopamine


Histamine release in the brain triggers secondary release of excitatory neurotransmitters such as glutamate and acetylcholine via stimulation of H1receptors in the cerebral cortex. Consequently unlike the H1 antagonist antihistamines which are sedating, H3 antagonists have stimulant and nootropic effects, and are being researched as potential drugs for the treatment of neurodegenerative conditions such as Alzheimer's disease.

Galanthamine extract is a specific, competitive and reversible acetylcholinesterase
inhibitor. It is used in the manufacture of 
medications, such as Nivalin and Reminyl, both of which have been approved by the FDA. They are a strong (reversible) cholinesterase inhibitor, increasing the susceptibility of organisms to acetylcholine, and treat for mild to moderate dementia of Alzheimer's type in clinic.

Huperzine A is also an acetylcholinesterase inhibitor, Damage to the cholinergic (acetylcholine-producing) system causes memory deficits associated with Alzheimer's disease. ACh has also been shown to promote REM sleep.  


Taking 200 milligrams of huperzine-A 30 minutes before bed can increase total REM by 20-30%. Huperzine-A, an extract of Huperzia serrata, slows the breakdown of the neurotransmitter acetylcholine. It is popular nootropic (smart drug), and I have used it in the past to accelerate learning and increase the incidence of lucid dreaming. I now only use huperzine-A for the first few weeks of language acquisition, and no more than three days per week to avoid side effects. Ironically, one documented side effect of overuse is insomnia. The brain is a sensitive instrument, and while generally well tolerated, this drug is contraindictated with some classes of medications. Speak with your doctor before using.


Neuro- transmitter:ACh
Acetylcholine

















Effects:↓Heart rate ↑Secretions (sweat, saliva) ↑Memory ↑Muscle contractions

Under healthy conditions REM sleep ‘turns-on' when activity levels of the biogenic amines (e.g. noradrenaline) decrease and activity levels ofacetylcholine increase. It is therefore not surprising to find that drugs that increase cholinergic activity generally tend to increase REM sleep and dream recall.

 Magnolia bark extract  contains eudesmol, an essential oil with possible antioxidant advantages.  Honokiol and magnolol (found in magnolia bark) can exert an increase in acetylcholine.


Deprenyl (selegiline) pre-treatment has been shown to protect cholinergic neurons from toxicity.



*****Only 0.003% percent of eggs are infected. The translation is that only one in every 30,000 eggs is contaminated with salmonella. This gives you an idea of how uncommon this problem actually is, so don't live in fear....down the hatch with those raw eggs, just like Rocky Balboa.

 You may feel sick and have loose stools, but this infection is easily treated by using high-quality probiotics that have plenty of good bacteria.  The majority of the people who contract salmonella aggressively using probiotics as treatment,just suffer with symptoms for a few hours.


Possible signs and symptoms of salmonella: include:Nausea, Vomiting, Abdominal pain, Diarrhea, Fever,, Chills Headache, Muscle pains and blood in the stool.  Signs and symptoms of salmonella infection generally last four to seven days, although it may take several months for your bowels to return to normal.

Saturday, June 15, 2013

Rapid recovery from major depression using magnesium treatment.

 Magnesium deficiency is occurring at epidemic rates, 80% is one estimate.   Magnesium  rbc (red blood cell testing) is the most accurate test,  serum magnesium tests are worthless.

Mega Dose magnesium sulfate increases testosterone levels in animal studies.

From a nutritional perspective, several research studies have shown certain minerals to be an effective natural insomnia remedy to help people fall asleep and stay asleep throughout the night. James F. Balch, M.D., author of Prescription for Nutritional Healing, writes: "A lack of the nutrients calcium and magnesium will cause you to wake up after a few hours and not be able to return to sleep."
Calcium is directly related to our cycles of sleep. In one study, published in the European Neurology Journal, researchers found that calcium levels in the body are higher during some of the deepest levels of sleep, such as the rapid eye movement (REM) phase. The study concluded that disturbances in sleep, especially the absence of REM deep sleep or disturbed REM sleep, are related to a calcium deficiency. Restoration to the normal course of sleep was achieved following the normalization of the blood calcium level.
William Sears, M.D. writes: "Calcium helps the brain use the amino acid tryptophan to manufacture the sleep-inducing substance melatonin. This explains why dairy products, which contain both tryptophan and calcium, are one of the top sleep-inducing foods."

Magnesium sulfate supplementation increases testosterone levels , and a magnesium-rich (brown rice) diet helps the elderly maintain testosterone levels.

There's been quite a bit of HYPE pimping MAGNESIUM L-THREONATE as a superior form of MAGNESIUM with claims of unique NOOTROPIC effects.

I've looked into what research exists to support these facts and I am sorry to report that the evidence simply does not stack up.

In short, there is conclusive substantiated scientific evidence that MAGNESIUM L-THREONATE does not in fact offer any superiority over MAGNESIUM SULFATE

The hype regarding MAGNESIUM L-THREONATE stems from claims that MAGNESIUM L-THREONATE increases BRAIN MAGNESIUM LEVELS to a greater extent than other magnesium forms, which would include MAGNESIUM SULFATE.

THIS IS A FALLACY

As is happens, administration of both MAGNESIUM SULFATE and MAGNESIUM L-THREONATE increase CEREBROSPINAL FLUID (CSF) LEVELS (= BRAIN LEVELS) of MAGNESIUM by exactly the same amount, namely 7-15%

The following study demonstrates that administration of MAGNESIUM SULFATE increases CEREBROSPINAL FLUID (CSF) LEVELS (= BRAIN LEVELS) of MAGNESIUM "by 15% and 11% relative to baseline":

Crit Care Med. 2005 Mar;33(3):661-6.

Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia.

McKee JA, Brewer RP, Macy GE, Phillips-Bute B, Campbell KA, Borel CO, Reynolds JD, Warner DS.

Source
Neurosciences Intensive Care Unit, Duke University Medical Center, Durham, NC, USA.


In magnesium deficiency, chronic insomnia is one of the main, central symptoms. Sleep is usually agitated with frequent nighttime awakenings. On the other hand, a high magnesium, low aluminum diet has been found to be associated with deeper, less interrupted sleep. This was proven in a study done by James Penland at the Human Nutrition Research Center in North Dakota. The study was titled "Effects of trace element nutrition on sleep patterns in adult women." It's important to note that a balanced ratio of calcium and magnesium is important to overall health, and these two minerals should be taken together for best results.



A magnesium deficiency CAN cause insomnia.
A study conducted at the Human Nutrition Research Center in North Dakota, "Effects of Trace Element Nutrition on Sleep Patterns in Adult Women," proved conclusively that a diet high in magnesium and low in aluminum led to sounder, longer sleep.Researchers at the East Texas Medical Center and the University of North Carolina have discovered that vitamin D helps to regulate the sleep-wake cycle.  They've found a definite link between vitamin D deficiency and the current global epidemic of sleep disorders. 




There is a wealth of evidence that Magnesium Orotate is beneficial in situations ranging from athletic performance to survival of heart disease patients.  

Restoration to the normal course of sleep was achieved following the normalization of the blood calcium level.  As a note, calcium works best when its balanced with magnesium in a two to one ratio (with twice as much calcium as magnesium).




What are the causes of hypomagnesemia?

David R. Mouw, MD, PhD; Robyn A. Latessa, MD
University of North Carolina, MAHEC Family Practice Residency,  Asheville, NC
Elaine J. Sullo, MLS
East Carolina University, Laupus Library,  Greenville, NC

  EVIDENCE-BASED ANSWER

The causes of magnesium depletion and hypomagnesemia are decreased gastrointestinal (GI) absorption and increased renal loss. Decreased GI absorption is frequently due to diarrhea, malabsorption, and inadequate dietary intake. Common causes of excessive urinary loss are diuresis due to alcohol, glycosuria, and loop diuretics.
Medical conditions putting persons at high risk for hypomagnesemia are alcoholism, congestive heart failure, diabetes, chronic diarrhea, hypokalemia, hypocalcemia, and malnutrition

Sixty percent of cases of clinical depression are considered to be treatment-resistant depression (TRD). Magnesium-deficiency causes N-methyl-d-aspartate (NMDA) coupled calcium channels to be biased towards opening, causing neuronal injury and neurological dysfunction, which may appear to humans as major depression. Oral administration of magnesium to animals led to anti-depressant-like effects that were comparable to those of strong anti-depressant drugs. Cerebral spinal fluid (CSF)magnesium has been found low in treatment-resistant suicidal depression and in patients that have attempted suicide. Brain magnesium has been found low in TRD using phosphorous nuclear magnetic resonance spectroscopy, an accurate means for measuring brain magnesium. http://www.sciencedirect.com/science/article/pii/S0306987709007300


Magnesium Deficiency
Insomnia is one of the central, or neurotic, symptoms of chronic magnesium deficiency.  A number of parasomnias (night terrors; nocturnal verbal and motor automatisms; restless legs syndrome) may be related to magnesium deficiency.  Sleep in magnesium deficiency is usually agitated with frequent nocturnal awakenings. Nocturnal instrument monitoring reveals major disorders of sleep organization. The deficiency may be severe enough to be diagnosed on the basis of clearly low blood magnesium levels. Conversely, a high magnesium, low aluminum diet has been found to be associated with high-quality sleep time and few nighttime awakenings, and magnesiumsupplementation has been reported to reduce sleep latency and result in uninterrupted sleep. 



Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125-300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use. Related and accompanying mental illnesses in these case histories including traumatic brain injury, headache, suicidal ideation, anxiety, irritability, insomnia, postpartum depression, cocaine, alcohol and tobacco abuse, hypersensitivity to calcium, short-term memory loss and IQ loss were also benefited. Dietary deficiencies of magnesium, coupled with excess calcium and stress may cause many cases of other related symptoms including agitation, anxiety, irritability, confusion, asthenia, sleeplessness, headache, delirium, hallucinations and hyperexcitability, with each of these having been previously documented. The possibility that magnesiumdeficiency is the cause of most major depression and related mental health problems including IQ loss and addiction is enormously important to public health and is recommended for immediate further study. Fortifying refined grain and drinking water with biologically available magnesium to pre-twentieth century levels is recommended.

Although the first report of magnesium treatment for agitated depression was published in 1921 showing success in 220 out of 250 cases, and there are modern case reports showing rapid terminating of TRD, only a few modern clinical trials were found. A 2008 randomized clinical trial showed that magnesium was as effective as the tricyclic anti-depressant imipramine in treating depression in diabetics and without any of the side effects of imipramine. Intravenous and oral magnesium in specific protocols have been reported to rapidly terminate TRD safely and without side effects. Magnesium has been largely removed from processed foods, potentially harming the brain. Calcium, glutamate and aspartate are common food additives that may worsen affective disorders. We hypothesize that – when taken together – there is more than sufficient evidence to implicate inadequate dietary magnesium as the main cause of TRD, and that physicians should prescribe magnesium for TRD. Since inadequate brain magnesium appears to reduce serotonin levels, and since anti-depressants have been shown to have the action of raising brain magnesium, we further hypothesize that magnesium treatment will be found beneficial for nearly all depressives, not only TRD.


Rapid recovery from major depression using magnesium treatment.

Source

George Eby Research, 14909-C Fitzhugh Road, Austin, TX 78736, USA. george.eby@coldcure.com

Abstract

Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism, anhedonia and sadness where these symptoms severely disrupt and adversely affect the person's life, sometimes to such an extent that suicide is attempted or results. Antidepressant drugs are not always effective and some have been accused of causing an increased number of suicides particularly in young people. Magnesium deficiency is well known to produce neuropathologies. Only 16% of the magnesium found in whole wheat remains in refined flour, and magnesium has been removed from most drinking water supplies, setting a stage for human magnesium deficiency. Magnesium ions regulate calcium ion flow in neuronal calcium channels, helping to regulate neuronal nitric oxide production. In magnesium deficiency, neuronal requirements for magnesium may not be met, causing neuronal damage which could manifest as depression. Magnesium treatment is hypothesized to be effective in treating major depression resulting from intraneuronal magnesium deficits. These magnesium ion neuronal deficits may be induced by stress hormones, excessive dietary calcium as well as dietary deficiencies of magnesium. Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125-300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use. Related and accompanying mental illnesses in these case histories including traumatic brain injury, headache, suicidal ideation, anxiety, irritability, insomnia, postpartum depression, cocaine, alcohol and tobacco abuse, hypersensitivity to calcium, short-term memory loss and IQ loss were also benefited. Dietary deficiencies of magnesium, coupled with excess calcium and stress may cause many cases of other related symptoms including agitation, anxiety, irritability, confusion, asthenia, sleeplessness, headache, delirium, hallucinations and hyperexcitability, with each of these having been previously documented. The possibility that magnesium deficiency is the cause of most major depression and related mental health problems including IQ loss and addiction is enormously important to public health and is recommended for immediate further study.